Modification of Ca2+-Sensitivity of Ca2+-Activated Cl- Channel by Vasopressin and Cholera Toxin.
- 1 January 1993
- journal article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 43 (4) , 553-560
- https://doi.org/10.2170/jjphysiol.43.553
Abstract
The apical membrane of renal epithelium (A6) had a Ca(2+)-activated, outwardly rectified chloride channel with the single channel conductance of 3 pS for outward current and 0.5 pS for inward current. The outward rectification was dependent on the cytosolic Ca2+ concentration. Vasopressin (arginine vasopressin, AVP) and cholera toxin (CTX) increased the single channel conductance for inward current through an increase in the Ca(2+)-sensitivity about 100-fold.Keywords
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