Recent Progress in .ALPHA.1-Adrenoceptor Pharmacology.
- 1 January 2002
- journal article
- duplicate publication
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 25 (4) , 401-408
- https://doi.org/10.1248/bpb.25.401
Abstract
The adrenoceptors (ARs) play a key role in the modulation of sympathetic nervous system activity and are a site of action for many clinically important therapeutic agents. The alpha1-adrenoceptor subtypes (alpha1A-, alpha1B-, and alpha1D-AR) play a prominent role in regulating vascular tone and hypertrophic growth of smooth muscle and cardiac cells. Their functional characteristics with respect to ligand binding and second messenger utilization have been well described. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of alpha1-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the alpha1-ARs.Keywords
This publication has 57 references indexed in Scilit:
- Parallel Regulation of Mitogen-activated Protein Kinase Kinase 3 (MKK3) and MKK6 in Gq-signaling CascadePublished by Elsevier ,2001
- Genetic Variations and Polymorphisms of G Protein-Coupled Receptors: Functional and Therapeutic ImplicationsAnnual Review of Pharmacology and Toxicology, 2001
- Regulation of Mitogen-Activated Protein Kinases in Cardiac Myocytes through the Small G Protein Rac1Molecular and Cellular Biology, 2001
- Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the α1b-adrenoceptorEuropean Neuropsychopharmacology, 2000
- α1-Adrenoceptor Subtypes Differentially Couple to Growth Promotion and Inhibition in Chinese Hamster Ovary CellsBiochemical and Biophysical Research Communications, 2000
- α‐Adrenergic inhibition of proliferation in HepG2 cells stably transfected with the α1B‐adrenergic receptor through a p42MAP kinase/p21Cip1/WAF1‐dependent pathwayFEBS Letters, 1998
- Real-Time Optical Monitoring of Ligand-Mediated Internalization of 1b-Adrenoceptor with Green Fluorescent ProteinMolecular Endocrinology, 1998
- Cloning, functional expression and tissue distribution of human α1C‐adrenoceptor splice variantsFEBS Letters, 1995
- A novel genetic system to detect protein–protein interactionsNature, 1989
- Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells.Journal of Clinical Investigation, 1989