Embryo transfer in the analysis of teratological responses of mice: A critical examination

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Abstract
Although the technique of embryo transfer has been used extensively in preimplantation mammalian embryology, its role in experimental teratology will probably be quite. This statement is based on the authors' personal experience, a review of other studies employing the technique, and a reexamination of certain fundamental principles of teratology. The experiment reported here involved cleft palate induced by triamcinolone acetonide in the SWV (sensitive) and C57BL/10J (less sensitive) strains of inbred mice. Despite technical success in transferring embryos between the two strains, the cleft palate results were not consistent with those of the natural mating studies and were inconclusive. In contrast, fetal death due to triamcinolone was strongly nfluenced by the genotype of the famale, in both natural and embryo transfer pregnancies.