Effects of Maternal and Embryonic Genotype on Prenatal Survival in Two Selected Mouse Lines

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Abstract
The effect of fetal and maternal genotype on embryo survival was studied in two lines of mice from the same base population: line E, selected for high embryo survival, and line CN-, selected for small litter size. Embryos were collected at 3.5 days postcoitus from normally mated donors of both lines and were transferred to the uteri of 2.5-day pseudopregnant recipients from each line. The number of embryos recovered and the proportion of those recovered that had been fertilized were greater in line E donors than in line CN- donors (P<.05). Development into blastocysts was slower for CN- embryos. The proportion of recipient females that were pregnant was higher for line E than for line CN- after transfer of line E embryos (P<.005). The same trend was observed following transfer of line CN- embryos (P<.10). Embryos of both lines showed greater survival when transferred to line E recipients than when transferred to line CN- recipients (P<.005), and, within line E recipients, E embryos tended to survive better than did CN- embryos (P<.10). The results suggest that although the genotype of the embryo may play a role, the maternal genotype has greater influence on embryo survival in the two lines of mice. Copyright © 1980. American Society of Animal Science . Copyright 1980 by American Society of Animal Science

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