Osmotic Ultrafiltration with Dextran Sodium Sulfate Potential for use in Peritoneal Dialysis

1 January 1979

journal article
research article
Published by Taylor & Francis in Journal of Dialysis

Vol. 3 (2-3) , 251-264
https://doi.org/10.3109/08860227909063944

Abstract

Dextran sodium sulfate was evaluated in vitro as a potential non-absorbable osmotic agent for peritoneal dialysis. It was compared to poly(sodium acrylate) which has been shown previously to be effective in rats, but probably toxic. Dextran sodium sulfate induced osmotic ultrafiltration rates as high as 20 ml/min in water but only 2 ml/min in solution containing non-polymer electrolytes presumably because of Gibbs-Donnan effects. Compared to acrylate the dextran polymer has less sodium per gram, lower osmotic activity of polymer sodium, and yields less ultrafiltration at given transmembrane osmolalities. A nontoxic polymer more like acrylate would seem more promising as an osmotic agent for peritoneal dialysis.

Keywords

This publication has 2 references indexed in Scilit:

Fluid and Electrolyte Complications of Peritoneal Dialysis
Annals of Internal Medicine, 1971
THE USE OF DEXTRAN AS A DIALYSING FLUID IN PERITONEAL DIALYSIS
Acta Medica Scandinavica, 1969