The functional role of the noradrenergic neurons in the thermoregulatory circuits in mice

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Abstract
Summary Intracerebroventricular (i.c.v.) treatment of mice with 6-hydroxydopamine (6-OHDA; 20–50μg per mouse), which depletes brain noradrenaline (NA) and DA, completely prevents or significantly diminishes the hypothermie effect of various classes of drugs: dopaminomimetics-apo-morphine (0.5–10 mg/kg), piribedil (40–100 mg/kg), bromocriptine (3 to 10mg/kg), CM 29–712 (2–10 mg/kg), d, 1-amphetamine (1–2 mg/kg), and L-DOPA (10–100 mg/kg) in combination with Ro 4–4602 (5–40 mg/kg); cholinomimetics-oxotremorine (0.04–0.05 mg/kg), arecoline (5–10 mg/kg) and pilocarpine (2–3 mg/kg); neuroleptics-chlorpromazine, promazine, perphenazine, chlorprothixene, haloperidol, fluanisone (5–10 mg/kg); centralα-adrenoblocker aceperone (20–40 mg/kg); inhibitor of tyrosinehydroxylaseα-methyltyrosine (200–300 mg/kg); inhibitors of dopamine-β-hydroxylase-disulfiram (150–250 mg/kg) and FLA-63 (15–25 mg/kg). This antihypothermic effect was demonstrated up to 3 months after administration of 6-OHDA for DA-mimetics and neuroleptics and up to 3 weeks for cholinomimetics. The hypothermie effect of presumable GABA-mimetics Phenybut (100–150 mg/kg) and Lioresal (10–25 mg/kg) was enhanced by a prior 6-OHDA treatment. Pretreatment of mice with desipramine (25 to 30 mg/kg i.p.), protriptyline (20 mg/kg) or AW 1511129 (15–20 mg/kg) 20–45 min before 6-OHDA administration protects the central NA-ergic neurons from a destructive effect of 6-OHDA and partially or completely counteracts the antihypothermic as well as prohypothermic (in the case of GABA-mimetics) effect of 6-OHDA. In rats desipramine counteracted antihypothermic effect of 6-OHDA in the case of piribedil, but not of and especially in effects of a wide variety of drugs on body temperature in mice.

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