THE INFLUENCE OF BARBITURATES ON COUMARIN PLASMA LEVELS AND PROTHROMBIN RESPONSE*
Open Access
- 1 October 1961
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 40 (10) , 1797-1802
- https://doi.org/10.1172/jci104403
Abstract
Results obtained in guinea pig, dog and man show that pretreatment with barbiturates may antagonize the hypoprothrombinemic effect of coumarin anticoagulants. This effect has been correlated with lower plasma levels of the anticoagulant drugs. In man, route and timing of dosage significantly influence this barbiturate effect.Keywords
This publication has 12 references indexed in Scilit:
- ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS1960
- Effect of starvation, acenocoumarin and vitamin K on the coagulation pattern of the guinea pig.1959
- [The effect of barbiturate anesthetics on the blood coagulation system; thromboelastographic findings].1956
- [Interference of barbiturates in the action of tromexan].1955
- The control of prothrombin activity with tromexan therapyThe American Journal of Medicine, 1953
- THE BIOTRANSFORMATION OF ETHYL BISCOUMACETATE (TROMEXAN) IN MAN, RABBIT AND DOG1953
- THE PHYSIOLOGICAL DISPOSITION OF ETHYL BISCOUMACETATE (TROMEXAN) IN MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL1952
- The Effect of Water-Soluble Preparations of Vitamin K in Dicumarol-Induced HypoprothrombinemiaNew England Journal of Medicine, 1950
- A simply prepared, standardized, and relatively stable thromboplastin extract for estimation of prothrombin timeAmerican Heart Journal, 1950
- THE PHYSIOLOGICAL DISPOSITION OF DICUMAROL IN MAN1950