The Iron Content of the Tissues in Haemochromatosis, With Special Reference to the Brain

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Abstract
In a moderately advanced case of haemochromatosis, excessive deposits of Fe were found in all parts of the body, except the blood, which contained slightly less than normal. The central nervous system shared in this process but, though chemically the brain contained between 2 and 3 times the normal amount of Fe, this excess was not demonstrable by histological methods. The essential feature of the disease appears to be an increased avidity of the tissues for Fe which slowly accumulates in a form they are incapable of excreting. The time necessary for deposition of the Fe found in this case (19 gm.) suggests that the disease is an inborn error of metabolism, the clinical symptoms of which do not appear till middle life.

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