Effect of Cyclic Nucleotides on DNA Synthesis in Mouse Lymphoid Cells

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Abstract
The effect of eight cyclic purine and cyclic pyrimidine nucleotides on DNA synthesis on mouse lymphoid cells was investigated. Two out of eight compounds tested, namely 2′,3′-cyclic guanosine monophosphate (2′,3′-cGMP) as well as 3′,5′-cyclic guanosine monophosphate (3′,5′-cGMP), stimulate thymidine incorporation in all types of lymphocytes tested. The stimulatory activity of the cyclic guanosine nucleotides as well as the effects of lectins could be antagonized by 3′,5′-cyclic adenosine monophosphate (3′,5′-cAMP). 2′,3′-cGMP seems to stimulate preferentially mature T-cells while 3′,5′-cGMP preferentially acts on B-cells.