Newcastle Virus: Conversion of Spherical Forms to Filamentous Forms

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Abstract
Study of Newcastle virus in allantoic fluid shows this virus to have a roughly spherical shape when examined under the electron microscope. Most of the particles maintain this form when purified by ultra-centrifugation and by transfer to water. The addition of .07 to .15 M sodium chloride to the solution converts it from the spherical to the filamentous form previously described. This conversion is prevented by partial inactivation with formaldehyde, mustard gas, or gentle heating.

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