STIMULATION OF OVINE PLACENTAL CALCIUM TRANSPORT BY PURIFIED NATURAL AND RECOMBINANT PARATHYROID HORMONE‐RELATED PROTEIN (PTHrP) PREPARATIONS
- 10 July 1989
- journal article
- research article
- Published by Wiley in Quarterly Journal of Experimental Physiology
- Vol. 74 (4) , 549-552
- https://doi.org/10.1113/expphysiol.1989.sp003303
Abstract
Perfusion in situ of the placenta of previously thyroparathyroidectomized fetal lambs has been used to compare the ability of various forms of parathyroid hormone-related protein (PTHrP) to stimulate placental calcium transport. Whereas PTHrP (1-34) was without effect, PTHrP (1-141) was active but usually after a delay of up to 1, in common with the effect noted when using extracts of fetal parathyroid glands. In contrast, PTHrP (1-84) and PTHrP (1-108), tended to show a more rapid stimulatory action. It is suggested that post-translational processing of PTHrP (1-141) may occur as an activating step in the placenta in vivo.This publication has 5 references indexed in Scilit:
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