IDENTIFICATION OF A RECEPTOR FOR COMPLEMENT ON GUINEA-PIG ALVEOLAR MACROPHAGE MEMBRANE

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Abstract
When target cells were prepared using mouse serum as the complement source, no attachment or ingestion of the target cell by guinea pig PAM [alveolar macrophages] was observed. When fresh autologous guinea pig serum was used as the complement source, attachment and ingestion of the target cell by PAM were observed. The attachment of these target cells was mediated by a complement receptor. Like human PAM, guinea pig PAM possess a membrane receptor for complement.