Studies on peptides. LXXVI. Synthesis of kassinin, a new frog skin peptide.
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (4) , 1231-1235
- https://doi.org/10.1248/cpb.26.1231
Abstract
Kassinin, a dodecapeptide amide with smooth muscle contractile activity isolated by Erspamer from the skin of Kassina senegalensis, was synthesized by deprotection of Z(OMe)-Asp(OBzl)-Val-Pro-Lys(Z)-Ser-Asp(OBzl)-Gln-Phe-Val-Gly-Leu-Met(O)-NH2 with methanesulfonic acid, followed by reduction of the Met(O) residue to Met with 2-mercaptoethanol. The contractile activity of synthetic kassinin in isolated guinea pig ileum was 0.4 of that of synthetic substance P.This publication has 0 references indexed in Scilit: