ARTERY-TO-MUSCLE ONSET TIME FOR NEUROMUSCULAR BLOCKING DRUGS

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Abstract
Artery-to-muscle (A-M) onset time for five neuromuscular blocking agents wan studied in 50 female patients under light endotracheal anaesthesia. Circulation to the right arm was occluded by a tourniquet and relased 1 min aftu the injection i.v. into the left arm of a myoneural blocking drug. Muscle twitches were recorded in the right hand after stimulation of the ulnar nerve (1 Hz). After releasing the tourniquet the response to single twitches continued without dearase in height (latent onset time). The onset of gradual decreases in twitch height was noted, and the time until 90% depression of twitch height was measured (manifest onset time). The mean latent onset times were: pancuronium 31.9 s, tubocurarine 21 s, alcuronium 17.2 s, fazadinium 8.6 s and auxamethonium 4.8 s. Mean A-M latent onset time was significantly differcut for each drug (P,0.005). Manifest A-M onset times were related to A-M latent onset times except for tubocurarine which exhibited a slower decline in twitch height. A-M latent onset time correlated well with the dues for intravenous onset times reported in the literature.

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