Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
- 15 January 1988
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4837) , 268-275
- https://doi.org/10.1126/science.3276003
Abstract
Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function. These molecules can serve as the sole means by which particular cell-surface proteins are anchored to the membrane. Lipids with similar structures may also be involved in signal transduction mechanisms for the hormone insulin. The utilization of this novel class of lipid molecules for these two distinct functions suggests new mechanisms for the regulation of proteins in biological membranes.Keywords
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