ACTINOMYCIN-D ENHANCEMENT OF GLUTAMINE SYNTHETASE ACTIVITY IN CHICK EMBRYO RETINAS CULTURED IN THE PRESENCE OF CORTISOL
Open Access
- 1 October 1971
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 51 (1) , 303-311
- https://doi.org/10.1083/jcb.51.1.303
Abstract
Cortisol can prematurely induce glutamine synthetase activity in the chick embryo retina. Under appropriate conditions, this effect can be enhanced by addition of low levels of actinomycin D; this enhancement is reversibly inhibited by cycloheximide. The magnitude of the effect is a function of time of exposure to hormone as well as antibiotic and is also a function of the age of the embryo; within the limits of the present study it did not appear to be a function of actinomycin-D concentration. The data are discussed in terms of current ideas of possible control mechanisms in animal cells.Keywords
This publication has 15 references indexed in Scilit:
- GLUTAMINE SYNTHETASE IN THE NORMAL AND DYSTROPHIC MOUSE RETINAThe Journal of cell biology, 1971
- A Sensitive Assay for GlutamyltransferaseEnzyme, 1971
- Control of Specific Gene Expression in Higher OrganismsScience, 1969
- CONTROL OF SPECIFIC GENE EXPRESSION EXAMINED IN SYNCHRONIZED MAMMALIAN CELLSProceedings of the National Academy of Sciences, 1969
- Induction of glutamine synthetase in chick embryo retina effects of serum and of steroid structureBiochimica et Biophysica Acta (BBA) - General Subjects, 1968
- ENZYME INDUCTION IN EMBRYONIC RETINA: THE ROLE OF TRANSCRIPTION AND TRANSLATIONProceedings of the National Academy of Sciences, 1968
- "Superinduction" of tyrosine transaminase in hepatoma cell cultures: differential inhibition of synthesis and turnover by actionomycin D.Proceedings of the National Academy of Sciences, 1968
- Effect of inhibitors of nucleic acid synthesis on steroid-mediated induction of tyrosine aminotransferase in hepatoma cell culturesJournal of Molecular Biology, 1967
- Precocious induction of retinal glutamine synthetase by hydrocortisone in the embryo and in culture. Age-dependent differences in tissue responseBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Stimulation by hydrocortisone of premature changes in the developmental pattern of glutamine synthetase in embryonic retinaBiochimica et Biophysica Acta (BBA) - General Subjects, 1966