Teratologic evaluation of synthetic Δ9‐tetrahydrocannabinol in rats
- 1 February 1975
- journal article
- Published by Wiley in Teratology
- Vol. 11 (1) , 99-101
- https://doi.org/10.1002/tera.1420110112
Abstract
Δ9‐Tetrahydrocannabinol (THC) was dissolved in propylene glycol and 25, 50, or 100 mg/kg administered daily sc to pregnant Charles River Sprague‐Dawley rats on days 6–15 of gestation (presence of sperm considered day 1). Maternal weight gain was depressed, but a significant decrease in fetal weight occurred only in the 50 mg/kg group. No malformations were noted, only some abnormalities consisting of several instances of rudimentary 14th rib and soft or spongy spinal cords.Keywords
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