HER-2/neu Gene Amplification Compared With HER-2/neu Protein Overexpression and Interobserver Reproducibility in Invasive Breast Carcinoma
Open Access
- 1 June 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 113 (6) , 852-859
- https://doi.org/10.1309/vacp-vlqa-g9dx-vudf
Abstract
We compared the detection of HER-2/neu gene amplification by fluorescence in situ hybridization(FISH) with detection of HER-2/neu protein overexpressKeywords
This publication has 15 references indexed in Scilit:
- Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry for the Evaluation of HER-2/neu in Breast CancerJournal of Clinical Oncology, 1999
- How Should HER2 Status Be Determined?JNCI Journal of the National Cancer Institute, 1999
- Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.Journal of Clinical Oncology, 1998
- Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer researchBreast Cancer Research and Treatment, 1995
- Treatment of Early-Stage Breast CancerJAMA, 1991
- 4. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancerInternational Journal of Cancer, 1990
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989
- Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12–21.32Genomics, 1989
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987
- The neu oncogene encodes an epidermal growth factor receptor-related proteinNature, 1986