Cell-wall composition and viomycin resistance in Rhizobium meliloti

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Abstract
Mutation to viomycin-resistance in Rhizobium meliloti R21 resulted in an accumulation of phosphatidylcholine and phosphatidylethanolamine in the cell wall. Resistance to viomycin decreased when the excess lipid was removed by EDTA or when its synthesis was prevented by growth of normally resistant cells at 40 °C. Microelectrophoretic data showed binding of viomycin to the cell surface and it is proposed that the mechanism of resistance to viomycin is an immobilization of the antibiotic in the surface layers of the cell as a result of combination with phospholipid.

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