Comparison of neurokinin A and substance P on cardiovascular and airway function in man.
- 1 February 1988
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 25 (2) , 273-275
- https://doi.org/10.1111/j.1365-2125.1988.tb03302.x
Abstract
The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.This publication has 5 references indexed in Scilit:
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