Kinetic isotope effects. Part 4.—Bromination and detritiation of some ortho-substituted acetophenones in alkaline media
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Transactions of the Faraday Society
- Vol. 63, 993-996
- https://doi.org/10.1039/tf9676300993
Abstract
Measurements are reported on the rates of bromination and detritiation of a series of ortho-subsitituted acetophenones in aqueous alkaline media at 25°, and of ortho-methylacetophenone over a temperature range. The rates, which are higher than those for the corresponding meta- and para-substituted compounds, are discussed in relation to the acid strengths of the corresponding benzoic acids. The iostope effects are lower than for the meta- and para-substituted acetophenones, with the exception of ortho-methylacetophenone, for which the activation energy difference ET–EH(3.4 kcal/mole), the A-factor ratio (3 AT/AH= 16), and a curved Arrhenius plot for the deprotonation results at the lowest temperature reflect the importance of proton tunnelling.Keywords
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