Corticotropin Stimulation of Urethral Cornification

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Abstract
THERE IS NEED for a simple clinical procedure to determine whether or not the adrenal glands are elaborating biologically significant amounts of estrogenic hormones in the postmenopausal patient and to determine their ability to increase this estrogenic hormone production after the specific stimulation of disease, "stress," or adrenocorticotropic hormone (corticotropin). This need arises because of the proven ability of the adrenals to synthesize estrogenic hormones that contribute to the continued growth of advanced cancer of the breast and because of the availability of surgical adrenalectomy or medicinal suppression of adrenal cortical activity in the treatment of this disease. The question of whether or not a specific carcinoma of the breast is stimulated by estrogens on the one hand, or is best treated by their massive administration on the other, is one that cannot easily be settled on the basis of present methods of study. An "estrogen stimulation test" has been