LOCAL MITOGENIC EFFECT OF TISSUE MAST CELL SECRETION

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Abstract
The effect of drug-induced mast cell secretion on proliferation was studied in fibroblast-like and mesothelial-like cells in organ-cultured rat mesentery. Mast cell degranulation achieved by compound 48/80 [p-methoxyphenethyl methylamine formaldehyde product] was followed by a marked mitogenic reaction in the surrounding tissue cells. The drug lacked mitogenic effect on cultured guinea pig mesentery, the mast cells of which are unresponsive to the drug, and on a human normal fibroblast-like cell line. Histamine at .apprx. 10-10 M, a major mast cell component, induced marked mitogenesis in guinea pig mesentery without causing degranulation of mast cells. Secreting rat-tissue mast cells release a mitogenic factor or factors acting locally on nearby tissue cells.