The involvement of calcium in the stimulation of respiration in isolated rat hepatocytes by adrenergic agonists and glucagon
- 18 August 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 204 (2) , 198-202
- https://doi.org/10.1016/0014-5793(86)80811-0
Abstract
The effects of adrenergic agonists and glucagon on respiration and cytosolic free Ca2+ measured with quin2, in female rat hepatocytes have been compared. In the presence of lactate, all three agonists caused a permanent stimulation of respiration. However, unlike phenylephrine, glucagon induced only a transient increase in cytosolic free Ca2+ and isoprenaline caused no detectable change. Mechanisms other than Ca2+ for respiratory stimulation by cAMP-linked agonists in liver are indicated.Keywords
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