Effect of anti-HLA antisera on macrophage-T-cell interactions.

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Abstract
Human T [thymus-derived] lymphocytes proliferated in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement. Macrophages pulsed for 18 h with antigen and then washed were capable of triggering T cell proliferation. Addition of anti-DRw but not anti-HLA (A and B loci) antisera during the pulse period inhibited the macrophages'' ability to trigger T cell proliferation. Human T cells apparently recognize and proliferate in response to antigen presented by the macrophages in association with Ia-like antigens.