Accounting for plasma levels below detection limits in a one-compartment zero-order absorption pharmacokinetics model

1 November 2002

journal article
research article
Published by Taylor & Francis in Journal of Applied Statistics

Vol. 29 (8) , 1181-1190
https://doi.org/10.1080/0266476022000011256

Abstract

We provide a simple method for fitting a one-compartment, zero-order absorption pharmacokinetics model in the presence of observations below the detection limit. This method may be extended to more complex pharmacokinetics models. We demonstrate, using a small simulation study, that the method provides accurate parameter estimates over a range of detection limits and we compare it to an ad hoc midpoint method. An applied example is provided from a pharmacokinetic investigation of a nicotine nasal spray.

Keywords

This publication has 4 references indexed in Scilit:

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