The FcγRIIa Polymorphism in Children with Atopic Diseases

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Abstract
Background: Fcγ receptor II (FcγRIIa) is the most widely distributed of the classes of FcR and is expressed in polymorphic forms on most types of hematopoietic cells. Recent data suggest that this polymorphism may be relevant to FcγRIIa function. This might be linked to variability in immune response and therefore related to the pathogenesis of atopic diseases. The aim of the study was to evaluate the FcγRIIa polymorphism in children with atopic diseases. Methods: In the study were included 140 atopic children, 77 with food allergy and 126 healthy subjects as the control group. The FcγRIIa polymorphism was determined using the polymerase chain reaction method. Results: The distribution of FcγRIIa genotypes in atopic children did not differ from that of healthy controls. Moreover, there was no association between the FcγRIIa genotypes and atopic diseases. Conclusion: It seems that the FcγRIIa polymorphism does not represent an important genetic risk factor for atopic diseases susceptibility.