Total Synthesis of Siccayne

Abstract
The palladium-catalyzed C-C coupling of 2-bromohydroquinone bis(methoxymethyl ether) with 2-methyl-3-butyn-2-ol is a key step in the six-step synthesis of the natural product siccayne [4-(2,5- dihydroxyphenyl)-2-methyl-1-buten-3-yne] from 1,4-benzoquinone.

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