SUBSTITUENT EFFECT ON RIBONUCLEASE T1-CATALYZED TRANSPHOSPHORYLATION OF para-SUBSTITUTED BENZYL ESTERS OF GUANOSINE 3′-PHOSPHATE
- 5 June 1975
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 4 (6) , 551-556
- https://doi.org/10.1246/cl.1975.551
Abstract
The maximal velocities have been measured for the ribonuclease T1- catalyzed transphosphorylation of a series of substrates named in the title. Based on the present results together with other relevant data, it is concluded that the catalysis involves nucleophilic component as well as electrophilic character, and the breakdown of a pentacovalent intermediate is not rate-limiting. We have proposed a possible mechanism most pertinent to a description of the ribonuclease T1 action.This publication has 15 references indexed in Scilit:
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