Polyfluoroaralkyl amines. Further studies on the reactivity of 4,5,6,7-tetrafluoroindole
- 1 November 1989
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 67 (11) , 1837-1841
- https://doi.org/10.1139/v89-285
Abstract
4,5,6,7-Tetrafluoroindole 1 undergoes electrophilic formylation and aminoalkylation at C-3 to give compounds that can be readily converted to a variety of products, including the skatole, tryptamine, and tryptophan. 1 reacts with ethyl diazoacetate to yield 4,5,6,7-tetrafluoroethyl-3-indole acetate. The Grignard reagent of 1 offers a direct route to the versatile substituted acetonitrile 10 via C-3 alkylation with chloroacetonitrile. Keywords: tetrafluoroindole, tetrafluorotryptamine, tetrafluoroindolyl magnesium bromide, tetrafluorotryptophan.This publication has 0 references indexed in Scilit: