Activated c-Abl tyrosine kinase in malignant solid tumors
- 7 April 2008
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 27 (32) , 4385-4391
- https://doi.org/10.1038/onc.2008.86
Abstract
Mutant forms of the c-ABL gene are well known to be involved in hematopoietic malignancies such as chronic myeloid leukemia (CML). CML patients possess a fused BCR-ABL gene that activates the Abl tyrosine kinase domain within Bcr-Abl. In general fusion proteins that cause oligomerization of Abl lead to activation of its tyrosine kinase activity. In this review, we highlight recent discoveries indicating that the activated c-Abl tyrosine kinase, not as a fusion protein, plays an important role in malignant solid tumors of lung and breast.Keywords
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