Antagonistic Action of Aerosols of Prostaglandins F2 and E2 on Bronchial Muscle Tone in Man
- 22 July 1972
- Vol. 3 (5820) , 212-213
- https://doi.org/10.1136/bmj.3.5820.212
Abstract
Experiments were carried out in healthy male volunteers to investigate the effect of the inhalation of prostaglandin F2α (PGF2α) on airways resistance and the influence of the subsequent inhalation of prostaglandin E2 (PGE2). Airways resistance, which reflects the tone of smooth muscle in the larger airways in man, was measured by total body plethysmography. The inhalation of PGF2α (40-60 μg) caused an increase in airways resistance in all subjects. Both PGE2 (55 μg) and isoprenaline (550 μg) given by metered aerosol promptly reversed the bronchoconstriction induced by PGF2α, but isoprenaline was more effective in this respect. A role for these prostaglandins in the control of bronchial muscle tone is discussed.Keywords
This publication has 3 references indexed in Scilit:
- DISTRIBUTION OF PROSTAGLANDINS IN HUMAN TISSUESBritish Journal of Pharmacology and Chemotherapy, 1967
- Acute effects of inhalation of cigarette smoke on airway conductanceJournal of Applied Physiology, 1961
- A NEW METHOD FOR MEASURING AIRWAY RESISTANCE IN MAN USING A BODY PLETHYSMOGRAPH: VALUES IN NORMAL SUBJECTS AND IN PATIENTS WITH RESPIRATORY DISEASE 1Journal of Clinical Investigation, 1956