Regulation of the Germinal Center Response by MicroRNA-155
Top Cited Papers
- 27 April 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 316 (5824) , 604-608
- https://doi.org/10.1126/science.1141229
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.Keywords
This publication has 23 references indexed in Scilit:
- AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2Cell, 2007
- NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesProceedings of the National Academy of Sciences, 2006
- Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic miceProceedings of the National Academy of Sciences, 2006
- Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β HeterodimerCell, 2004
- High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphomaGenes, Chromosomes and Cancer, 2003
- High-throughput engineering of the mouse genome coupled with high-resolution expression analysisNature Biotechnology, 2003
- Avian bic , a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c- myc in Lymphomagenesis and ErythroleukemogenesisJournal of Virology, 2002
- NEMO/IKKγ-Deficient Mice Model Incontinentia PigmentiMolecular Cell, 2000
- Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG ResponsesThe Journal of Experimental Medicine, 1997
- Clonal selection and learning in the antibody systemNature, 1996