Cytochrome P-450 Polymorphisms and Response to Clopidogrel
Top Cited Papers
- 22 January 2009
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 360 (4) , 354-362
- https://doi.org/10.1056/nejmoa0809171
Abstract
Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function.Keywords
This publication has 31 references indexed in Scilit:
- Usefulness of Left Ventricular Conic Index Measured by Real-Time Three-Dimensional Echocardiography to Predict Left Ventricular Remodeling After Acute Myocardial InfarctionThe American Journal of Cardiology, 2008
- Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal StentsJournal of the American College of Cardiology, 2008
- Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trialThe Lancet, 2008
- Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrelJournal of Thrombosis and Haemostasis, 2007
- Prasugrel versus Clopidogrel in Patients with Acute Coronary SyndromesNew England Journal of Medicine, 2007
- Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome of Elective Coronary Stent PlacementJournal of the American College of Cardiology, 2006
- INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450Drug Metabolism and Disposition, 2006
- Clopidogrel Effect on Platelet REactivity in Patients With Stent ThrombosisJournal of the American College of Cardiology, 2005
- Clopidogrel for Coronary StentingCirculation, 2003
- Clinical Significance of the Cytochrome P450 2C19 Genetic PolymorphismClinical Pharmacokinetics, 2002