Effect of Vinblastine and 4-Amino-N10 Methyl Pteroyl-Glutamic Acid On the Erythropoietin Responsive Cell.

Publisher Website
Google Scholar
Abstract
Vinblastine given in graded doses, 10-20-40 [mu]g, to polycythemic mice either before or after EP reduces their response to EP in proportion to log dose. Analysis of the dose response curve using Valeriote and Bruce model (5) suggests a generation time of about 9 hr. for the erythropoietin responsive unit (ERU). Methotrexate 50 mg/kg given either 8 hr. before, together with, or 4 hr. after EP completely suppresses the response to EP even though, followed after a 4-hr, interval by an injection of folinic acid which is known to reverse the methotrexate effect on cells. Most of ERU are in cell cycle; and respond to EP in Gi. The ERU population might be that segment of CFU [colony-forming unit] in cycle, Qr an intermediary population, capable of limited divisions, derived from it.

This publication has 0 references indexed in Scilit: