Busulfan and Veno-occlusive Disease of the Liver

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Abstract
To the Editor: High-dose busulfan in combination therapy is well known to be responsible for veno-occlusive disease of the liver in about 20% of adult patients undergoing bone marrow transplantation (1, 2). However, the incidence of this disease is lower (0% to 5%) in children (3). In our institution, from September 1979 to December 1990, 403 courses of high-dose chemotherapy were administered before bone marrow transplantation in children with solid tumors: 125 courses included high-dose busulfan. Two total busulfan doses were used: 16 mg/kg body weight in 64 courses and 600 mg/m2 body surface area in 61 courses. The dose