THE CINCINNATI LIPID RESEARCH CLINIC FAMILY STUDY - CULTURAL AND BIOLOGICAL DETERMINANTS OF LIPIDS AND LIPOPROTEIN CONCENTRATIONS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 34  (6) , 888-903
Abstract
A general linear model is described here for cultural and biological inheritance of lipids and lipoproteins. This model involves 10 parameters to be estimated from a total of 17 correlations, leaving ample degrees of freedom to test the goodness of fit. The model fits very well to each of the 5 lipid and lipoprotein variables analyzed here from a Lipid Research Clinic family data set. Genetic and cultural inheritance are significant for each trait with the single exception that triglyceride levels fail to support genetic inheritance. Under the most parsimonious hypothesis, the genetic heritabilty (h2) ranges from 0.194 .+-. 0.092 for triglyceride to 0.624 .+-. 0.093 for low-density lipoprotein-cholesterol. Cultural heritability ranges from 0.070 .+-. 0.030 for total cholesterol to 0.149 .+-. 0.034 for triglyceride.