The Effect of the Severity and Timing of Malnutrition on Brain Gangliosides in the Rat

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Abstract
Wistar albino rats were malnourished (a) by increasing the size of the litter at birth, (b) by rearing females from weaning on a 12% protein diet, and (c) by giving pregnant females a 7% protein diet during gestation and lactation. Rats on regimens (a) and (c) had low concentrations of ganglioside NANA in the forebrain and brain stem and on regimen (c) the absolute amount of NANA in the brain stem was less than that expected from the brain stem weight. It is suggested that the reduction in ganglioside NANA reflects a reduction in dendritic development.

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