Relation of intraintestinal carbon dioxide to intestinal blood flow

Publisher Website
Google Scholar
Abstract
The injection of 300 ml of increasing concentrations of CO2 gas into intestinal loops of pentobarbitalized dogs produced a progressive increase in superior mesenteric arterial blood flow as measured with an electromagnetic flowmeter. The percent of control superior mesenteric arterial blood flow appeared to be linearly related to the logarithm of the intraintestinal CO2 gas percentage. Reduction of intestinal blood flow by means of subcutaneous methacholine chloride pretreatment or partial occlusion of the superior mesenteric artery produced diminished rates of CO2 gas disappearance from intestinal loops. Aortic and superior mesenteric vein blood pCO2 and pH measurements in untreated and methacholine chloride-pretreated dogs indicated that inhibition of CO2 gas absorption was associated with a prolonged elevation of the superior mesenteric vein blood pCO2. These observations suggest that elevated intraintestinal CO2 gas concentrations increase intestinal blood flow which may facilitate the return of the intraintestinal CO2 concentration to basal levels.

This publication has 4 references indexed in Scilit: