INFLUENCE OF THE THYROID ON THE RESORPTION OF GONADOTROPIC HORMONES

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Abstract
The influence of thyroidectomy in augmenting the gonadotrophic response to the pituitary hormone given in single daily doses was considerably less than the augmentation produced by divided dosage or delayed resorption (insoluble Zn or Cu combination) of the same amt. of hormone in the normal rat. Under conditions (dosage as insoluble Cu combination) eliciting maximum gonadotrophic response for a given amt. of pituitary hormone, thyroidectomy was without influence. Thyroxin adm. counteracted the effect of thyroidectomy under conditions in which thyroidectomy augmented the response to the pituitary gonadotrophic hormone. The response to prolan was not greatly influenced by divided dosage or thyroidectomy, in contrast to the response to the pituitary hormone, which response was markedly influenced by divided dosage or thyroidectomy. When thyroidectomy exerts an augmentation effect, or thyroxin adm. exerts an antagonistic effect, the phenomena may be explained by the decrease or increase in rate of exchange of body fluids which these procedures bring about, so decreasing or increasing the rate of hormone resorption.