pH‐Dependence of the Mechanism in the Duodenal Bulb Inhibiting Gastric Acid Responses to Exogenous Gastrin

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Abstract
Gastric secretion was stimulated by intravenous infusion of gastrin n Pavlov and Heidenhain pouch dogs provided with isolated pouches of the duodenal bulb. Lowering the intrabulbar pH to pH 1.1 –1.3 almost abolished the acid response to a low dose of gastrin, whereas the inhibition of secretory responses to higher doses was less pronounced. Inhibition of secretory responses to a fixed submaximal dose of gastrin did not occur until the bulbar pH was reduced to 2.0–2.5. Secretory responses to threshold doses of gastrin, on the other hand, were significantly inhibited already at pH 3–4. The results question the concept that very low intra‐duodenal pH is required to activate the mechanism by which acid in the duodenum inhibits gastric acid secretion.