Chameleon catches in combinatorial chemistry: Tebbe olefination of polymer supported esters and the synthesis of amines, cyclohexanones, enones, methyl ketones and thiazoles
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 18,p. 2019-2020
- https://doi.org/10.1039/a805874a
Abstract
Tebbe olefination of supported esters R1CO2CH2–polymer gave the corresponding vinyl ethers R1C(CH2)OCH2–polymer which were released, under acidic conditions, to produce methyl ketones R1COMe; by reductive amination, to produce amines R1CH(Me)NHR2; by bromination and reaction of R1CBr(CH2Br)OCH2-polymer with thioureas to produce thiazoles; or, for supported dienyl ethers derived from α,β-unsaturated esters, by Diels–Alder reaction and acid mediated cleavage to produce cyclohexanone derivatives.Keywords
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