Heterogeneity of Virus Particles in Measles Virus

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Abstract
A heterogeneous population of virions is generated by measles virus-infected [human, monkey and mouse] cells. These particles are partially separable by sucrose density centrifugation into 3 peaks. Each population is stable and contains infectious particles. The particles of all 3 populations contain at least 6 polypeptide species that differ between particle populations only in quantity. All 3 populations contain a 50S RNA species, and the heaviest density peak also contains an additional species of 43S RNA. The difference between these results and previous studies with measles virions is discussed.