Effect of Amphetamine on Plasma Corticosterone in the Conscious Rat
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 29 (2) , 110-118
- https://doi.org/10.1159/000122912
Abstract
The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, the serotonergic depleting agent p-chloroamphetamine significantly inhibited the AMPH-induced rise in corticosterone. In addition, the serotonergic blocking agent methysergide, but not cyproheptadine, inhibited the corticosterone increase induced by AMPH.This publication has 6 references indexed in Scilit:
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