Response : On "Animal Hypnosis"
- 22 October 1948
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 108 (2808) , 437
- https://doi.org/10.1126/science.108.2808.437-a
Abstract
A structural formula is proposed for actidione. On alkaline hydrolysis the molecule is split into: NH3, 2,4-dimethylcyclohexaone, and, presumably, 3,3-propionaldehyde-diacetic acid. Oxidation of actidione yields a diketone, dehy-droactodione, which on alkaline hydrolysis is degraded to NH3, 2,4-dimethylcyclohexanone, and methanetriacetic acid. Elec-trometric titration of the antibiotic shows a weakly acidic group with a pK = 11.2. Catalytic reduction gives dihydroacti-dione which reacts with diazomethane to give N-methyldihydro-actidione.Keywords
This publication has 3 references indexed in Scilit:
- Prolonged Hypnotic States With "Local Signs" Induced in Guinea PigsScience, 1948
- Actidione, an Antibiotic from Streptomyces Griseus1Journal of the American Chemical Society, 1948
- ACTIDIONE, AN ANTIBIOTIC FROM STREPTOMYCES GRISEUSJournal of the American Chemical Society, 1947