The transcriptional control proteins c‐Myb and v‐Myb contain a basic region DNA binding motif
- 6 May 1991
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 282 (2) , 293-294
- https://doi.org/10.1016/0014-5793(91)80498-r
Abstract
A class of transcriptional control proteins, typified by c-Myb, are characterised by a highly conserved N-terminal DNA binding domain, which is composed of either 2 or 3 imperfect repeats of about 52 amino acids. A sequence homology search of the SWISSPROT protein sequence data bank with this region from mouse c-Myb has allowed us to identify an area near the C-terminus of repeat 2 that contains a short sequence motif, known as the basic region, which forms the DNA binding site in both leucine zipper and helix-loop-helix transcription factors. We therefore propose that this region of repeat 2 and the homologous part of repeat 3 will form the Myb DNA binding siteKeywords
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