Serotonin receptor modulation in irritable bowel syndrome: one step forwards and one step backwards

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Abstract
In the study reported here which was confined to women, alosetron was found to be significantly superior to placebo in providing “adequate relief of pain/discomfort” in patients with diarrhoea and improving bowel function in patients with both diarrhoea and an alternating bowel habit. A particularly noteworthy feature was that the advantage of alosetron was promptly lost when treatment was stopped, suggesting a real effect. The main side effect of treatment was constipation but one case of ischaemic colitis was also reported.

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