Isolation of drug-resistant H5N1 virus
Top Cited Papers
- 14 October 2005
- journal article
- case report
- Published by Springer Nature in Nature
- Vol. 437 (7062) , 1108
- https://doi.org/10.1038/4371108a
Abstract
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic1. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir2, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.Keywords
This publication has 9 references indexed in Scilit:
- Characterization of a Human H5N1 Influenza A Virus Isolated in 2003Journal of Virology, 2005
- Pandemic Influenza: Global UpdateScience, 2005
- Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivirAntiviral Research, 2004
- Selection of Influenza Virus Mutants in Experimentally Infected Volunteers Treated with OseltamivirThe Journal of Infectious Diseases, 2001
- Resistance of influenza viruses to neuraminidase inhibitors — a reviewAntiviral Research, 2000
- Influenza virus neuraminidase inhibitorsThe Lancet, 2000
- Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute InfluenzaJAMA, 2000
- Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolutionNature, 1983
- Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-d-N-acetylneuraminate) substrateAnalytical Biochemistry, 1979