Bone Marrow Transplantation for Severe Combined Immune Deficiency
Open Access
- 1 February 2006
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 295 (5) , 508-518
- https://doi.org/10.1001/jama.295.5.508
Abstract
Severe combined immune deficiency (SCID) is a heterogeneous group of inherited diseases with an estimated frequency of 1 in 50 000 to 100 000 live births.1 It is characterized by significant impaired immunity leading to death in infancy unless treated by hematopoietic stem cell transplantation. The optimal treatment for most patients with SCID is bone marrow transplantation (BMT) from a related, HLA-identical donor (RID).2 Unfortunately, such donors are found for only a minority of patients with SCID.3,4Keywords
This publication has 30 references indexed in Scilit:
- Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantationBone Marrow Transplantation, 2005
- Newborn screening for severe combined immunodeficiency (SCID): a reviewFrontiers in Bioscience-Landmark, 2005
- Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donorsBone Marrow Transplantation, 2004
- MolecularDefects inHumanSevereCombinedImmunodeficiency andApproaches toImmuneReconstitutionAnnual Review of Immunology, 2004
- Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responsesBlood, 2003
- Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99The Lancet, 2003
- Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantationSeminars in Hematology, 2002
- Matched unrelated bone marrow transplantation for combined immunodeficiencyBone Marrow Transplantation, 2000
- European experience of bone-marrow transplantation for severe combined immunodeficiencyThe Lancet, 1990
- Reconstitution in Severe Combined Immunodeficiency by Transplantation of Marrow from an Unrelated DonorNew England Journal of Medicine, 1977