ANTI-TUMOR EFFECT OF HUMAN FIBROBLAST INTERFERON ON THE GROWTH OF HUMAN-MELANOMA CELLS IMPLANTED IN NUDE-MICE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73  (6) , 952-960
Abstract
The antitumor effect of human fibroblast interferon (HuIFN-.beta.) on the growth of human melanoma cells (HMV-1) in vitro and in vivo was examined. In in vitro experiments, HMV-1 cells were highly sensitive to HuIFN-.beta. compared to other human cells. The cell growth in nude mice was also suppressed by daily administration of HuIFN-.beta., depending on the dosage and administration route. The most prominent effect was obtained by intratumoral injection and a lesser therapeutic effect was achieved by s.c. injection around the inoculated tumor. I.p. injection of HuIFN-.beta. was unsuccessful. Pharmacokinetic studies of HuIFN-.beta. in nude mouse indicated that the 3 administration routes gave similar blood plasma levels and decline curves, suggesting that there is no correlation between the plasma HuIFN-.beta. level and the therapeutic efficacy. A relatively high interferon titer was detected for a long time after intratumoral injection of HuIFN-.beta.. Because of the species specificity of interferon and the use of the nude mouse system lacking T-cell function, the antitumor effect observed might reflect an anticellular activity of HuIFN-.beta. retained in the tumor region.

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